Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.68 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.64 |
| ▸ | EGFR | P00533 | 3/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.60 |
| ▸ | USP1 | O94782 | 1/20 | 0.57 |
| ▸ | WDR48 | Q8TAF3 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | USP2 | O75604 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.57 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866944 | 0.90 | APP (0.68) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL3106193 | 0.89 | APP (0.70) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL4864375 | 0.89 | APP (0.60) | APPSLC2A1EGFRLMNACYP1A2 | |
| SCHEMBL4864671 | 0.89 | APP (0.70) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL4863020 | 0.88 | APP (0.71) | APPSLC2A1EGFRLMNACYP1A2 | |
| SCHEMBL3110568 | 0.88 | APP (0.71) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL92716 | 0.86 | APP (0.70) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL3115914 | 0.86 | APP (0.70) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL3119160 | 0.86 | APP (0.70) | APPSLC2A1EGFRPOLBNR2F2 | |
| SCHEMBL92685 | 0.86 | APP (0.73) | APPSLC2A1EGFRPOLBNR2F2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008526734-A | — | — | 2008-07-24 | — | — | JP | claimed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | claimed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |