Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRA1 | P14867 | 2/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.40 |
| ▸ | ERN1 | O75460 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8957163 | 0.85 | SRD5A1 (0.43) | GABRA1GABRB2ERN1KDM4EPOLB | |
| SCHEMBL299374 | 0.85 | SELL (0.41) | GABRA1GABRB2KDM4EPOLBTSHR | |
| SCHEMBL9764452 | 0.83 | KDM4E (0.36) | GABRA1GABRB2MAPK1KDM4EPOLB | |
| SCHEMBL8852216 | 0.80 | KDM4E (0.36) | GABRA1GABRB2MAPK1KDM4EPOLB | |
| SCHEMBL14058648 | 0.80 | KDM4E (0.42) | ERN1MAPK1KDM4ESRD5A1MAPT | |
| SCHEMBL8824319 | 0.78 | GABRA1 (0.44) | GABRA1GABRB2KDM4EMAPTALDH1A1 | |
| SCHEMBL12611132 | 0.78 | GABRA1 (0.58) | GABRA1GABRB2MAPK1KDM4EMAPT | |
| SCHEMBL1005361 | 0.78 | GABRA1 (0.55) | GABRA1GABRB2MAPK1KDM4EPOLB | |
| SCHEMBL28289001 | 0.77 | ERN1 (0.38) | GABRA1GABRB2ERN1MAPK1KDM4E | |
| SCHEMBL15824990 | 0.75 | GABRA1 (0.41) | GABRA1GABRB2KDM4EPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411388-A2 | PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES | Elan Pharmaceuticals Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010111418-A2 | PROCESS FOR THE PRODUCTION OF FUSED, TRICYCLIC SULFONAMIDES | ELAN PHARMACEUTICALS, INC. (US) | 2010-09-30 | — | — | WO | disclosed |