SCHEMBL4861426

SCHEMBL4861426

COc1cccc(CNc2nc(CCc3ccccc3)nc3ccccc23)c1OC

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 12/20 0.54
CYP3A4 P08684 12/20 0.54
CYP2D6 P10635 12/20 0.54
CYP2C19 P33261 12/20 0.54
TSHR P16473 12/20 0.54
LMNA P02545 9/20 0.54
USP2 O75604 8/20 0.54
ALOX15 P16050 5/20 0.54
HSD17B10 Q99714 8/20 0.52
SMN1; SMN2 Q16637 6/20 0.52
MAPK1 P28482 3/20 0.52
CYP2C9 P11712 7/20 0.51
MEN1 O00255 5/20 0.51
KMT2A Q03164 5/20 0.51
HIF1A Q16665 1/20 0.51
ABCB1 P08183 2/20 0.49
ABCG2 Q9UNQ0 2/20 0.49
SLC2A1 P11166 1/20 0.49
ALDH1A1 P00352 5/20 0.48
TP53 P04637 4/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4861484 0.91 CYP1A2 (0.64) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL4868666 0.90 CYP1A2 (0.55) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL4912864 0.90 CYP1A2 (0.55) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL3117297 0.82 CYP1A2 (0.58) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL5273800 0.82 CYP1A2 (0.66) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL5270283 0.82 CYP1A2 (0.55) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL4867165 0.81 CYP1A2 (0.71) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL4860013 0.81 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL4859455 0.81 CYP1A2 (0.65) CYP1A2CYP3A4CYP2D6CYP2C19TSHR
SCHEMBL4868186 0.80 CYP1A2 (0.56) CYP1A2CYP3A4CYP2D6CYP2C19TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2008526734-A 2008-07-24 JP claimed
EP-1844023-A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY SK CHEMICALS CO., LTD. (KR) 2007-10-17 EP claimed
WO-2006071095-A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY SK CHEMICALS CO., LTD. (KR) 2006-07-06 WO claimed
EP-1844023-A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY SK CHEMICALS CO., LTD. (KR) 2007-10-17 EP disclosed
WO-2006071095-A1 QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY SK CHEMICALS CO., LTD. (KR) 2006-07-06 WO disclosed