Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 15/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 15/20 | 0.64 |
| ▸ | CYP2D6 | P10635 | 15/20 | 0.64 |
| ▸ | CYP2C19 | P33261 | 15/20 | 0.64 |
| ▸ | TSHR | P16473 | 13/20 | 0.64 |
| ▸ | LMNA | P02545 | 11/20 | 0.64 |
| ▸ | USP2 | O75604 | 11/20 | 0.64 |
| ▸ | ALOX15 | P16050 | 6/20 | 0.64 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 10/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 9/20 | 0.57 |
| ▸ | MEN1 | O00255 | 7/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.57 |
| ▸ | CLK4 | Q9HAZ1 | 6/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.57 |
| ▸ | TP53 | P04637 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | RECQL | P46063 | 2/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4861426 | 0.91 | CYP1A2 (0.54) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4860013 | 0.89 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4859455 | 0.89 | CYP1A2 (0.65) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5270283 | 0.88 | CYP1A2 (0.55) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL5273800 | 0.88 | CYP1A2 (0.66) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4859418 | 0.84 | ACHE (0.72) | MEN1KMT2AACHE | |
| SCHEMBL12175940 | 0.83 | SLC2A1 (0.70) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4868159 | 0.83 | APP (0.51) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4859121 | 0.82 | APP (0.68) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4864375 | 0.81 | APP (0.60) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008526734-A | — | — | 2008-07-24 | — | — | JP | claimed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | claimed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |