Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 3/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.35 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20138242 | 0.76 | MAPK1 (0.50) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL370542 | 0.74 | MAPK1 (0.49) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL9559956 | 0.73 | MAPK1 (0.48) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL5807114 | 0.73 | MAPK1 (0.44) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL11923732 | 0.71 | KMT2A (0.43) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL4886946 | 0.71 | AGTR1 (0.40) | KMT2AKDM4EALDH1A1HPGDTP53 | |
| SCHEMBL22890640 | 0.70 | SMN1; SMN2 (0.46) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL16851076 | 0.69 | LMNA (0.49) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL16851069 | 0.69 | LMNA (0.49) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL3228644 | 0.68 | KMT2A (0.45) | MAPK1KMT2ASMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008111794-A1 | 4-METHYLIMIDAZOL-5-YLCARBONYLGUANIDINE DERIVATIVES, PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF, PREPARATION METHOD, AND PHARMACEUTICAL COMPOSITIONS FOR THE PREVENTION AND TREATMENT OF THE ISCHEMIC HEART DISEASES CONTAINING THE SAME AS AN ACTIVE INGREDIENT | KOREA RESERACH INSTITUTE OF CHEMICAL TECHNOLOGY (KR) | 2008-09-18 | — | — | WO | disclosed |