SCHEMBL4861622

SCHEMBL4861622

Cc1c(F)nc(F)c(O)c1F

nearest known ligand 0.30

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 1/20 0.30
MAPT P10636 1/20 0.30
HTT P42858 1/20 0.30
KMT2A Q03164 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16707607 0.80 MEN1 (0.36) MEN1MAPTHTTKMT2A
SCHEMBL4854363 0.79 NOX1 (0.30) MEN1MAPTHTTKMT2A
SCHEMBL10869225 0.75 MEN1 (0.39) MEN1MAPTHTTKMT2A
SCHEMBL4855832 0.74
SCHEMBL25203101 0.70 MEN1 (0.32) MEN1MAPTHTTKMT2A
SCHEMBL25614066 0.69 MEN1 (0.39) MEN1MAPTHTTKMT2A
SCHEMBL2378177 0.68 LMNA (0.32) MEN1MAPTHTTKMT2A
SCHEMBL10870412 0.68 MEN1 (0.31) MEN1MAPTHTTKMT2A
SCHEMBL8734993 0.67 MEN1 (0.36) MEN1MAPTHTTKMT2A
SCHEMBL3180199 0.67 MEN1 (0.36) MEN1MAPTHTTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7470671-B2 Thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therapeutics LABORATOIRE FOURNIER (FR) 2008-12-30 US disclosed
US-20070054955-A1 Novel thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therepeutics. LABORATOIRES FOURNIER S.A. (FR) 2007-03-08 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070054955-A1 Novel thioxylose compounds, preparation method thereof, pharmaceutical compositions containing same and use thereof in therepeutics. NOTUM, STS, AGPS MEN1 3378/4885MAPT 4311/4885HTT 2562/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.