Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 6/20 | 0.64 |
| ▸ | BRAF | P15056 | 10/20 | 0.62 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | FYN | P06241 | 1/20 | 0.59 |
| ▸ | CSF1R | P07333 | 4/20 | 0.56 |
| ▸ | KIT | P10721 | 3/20 | 0.56 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | RAF1 | P04049 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14042471 | 0.94 | LCK (0.65) | LCKBRAFSRCFYNCSF1R | |
| SCHEMBL14042704 | 0.92 | BRAF (0.64) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL14042259 | 0.90 | BRAF (0.62) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL14042708 | 0.89 | BRAF (0.61) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL14042707 | 0.89 | BRAF (0.61) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL14042437 | 0.89 | BRAF (0.67) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL4750073 | 0.88 | BRAF (0.64) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL4746797 | 0.88 | LCK (0.64) | LCKBRAFCSF1RKIT | |
| SCHEMBL14042642 | 0.88 | BRAF (0.63) | LCKBRAFSRCCSF1RKIT | |
| SCHEMBL14042661 | 0.87 | BRAF (0.65) | LCKBRAFSRCCSF1RKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |
| WO-2008124393-A1 | BENZOTHIAZOLE DERIVATIVES AND THEIR USE AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2008-10-16 | — | — | WO | disclosed |