Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | LSS | P48449 | 1/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | VNN1 | O95497 | 3/20 | 0.42 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1448975 | 1.00 | L3MBTL3 (0.52) | L3MBTL3CDK1CDK2HRH3L3MBTL1 | |
| SCHEMBL1447551 | 0.84 | L3MBTL3 (0.69) | L3MBTL3HRH3L3MBTL1MGLLMCHR1 | |
| SCHEMBL1447249 | 0.84 | L3MBTL3 (0.69) | L3MBTL3HRH3L3MBTL1MGLLMCHR1 | |
| SCHEMBL1447315 | 0.84 | L3MBTL3 (0.69) | L3MBTL3HRH3L3MBTL1MGLLMCHR1 | |
| SCHEMBL17271879 | 0.78 | L3MBTL3 (0.84) | L3MBTL3HRH3L3MBTL1MGLLALDH1A1 | |
| SCHEMBL25975209 | 0.75 | L3MBTL3 (0.58) | L3MBTL3HRH3L3MBTL1MGLLALDH1A1 | |
| SCHEMBL26617906 | 0.75 | ALDH1A1 (0.39) | L3MBTL3CDK1CDK2L3MBTL1ALDH1A1 | |
| SCHEMBL1449252 | 0.75 | L3MBTL3 (0.49) | L3MBTL3HRH3L3MBTL1MGLLLSS | |
| SCHEMBL1449249 | 0.75 | L3MBTL3 (0.49) | L3MBTL3HRH3L3MBTL1MGLLLSS | |
| SCHEMBL20624048 | 0.74 | RECQL (0.57) | L3MBTL3L3MBTL1MGLLALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1912974-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | AstraZeneca AB (SE) | 2008-04-23 | — | — | EP | disclosed |
| WO-2007015064-A1 | IMIDAZOLYL-PYRIMIDINE COMPOUNDS FOR USE IN THE TREATMENT OF PROLIFERATIVE DISORDERS | ASTRAZENECA AB (SE) | 2007-02-08 | — | — | WO | disclosed |