Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.69 |
| ▸ | PPARG | P37231 | 3/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.57 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4872350 | 0.87 | PPARG (0.55) | HRH3PPARGADORA3 | |
| SCHEMBL4866951 | 0.81 | HRH3 (0.57) | HRH3PPARGADORA3 | |
| SCHEMBL874584 | 0.81 | ADORA3 (0.74) | HRH3PPARGADORA3EPHX1ALDH1A1 | |
| SCHEMBL4871188 | 0.80 | PPARD (0.57) | HRH3PPARG | |
| SCHEMBL25258250 | 0.79 | ADORA3 (0.71) | HRH3PPARGADORA3EPHX1ALDH1A1 | |
| SCHEMBL4866992 | 0.79 | HRH3 (0.54) | HRH3PPARGADORA3ALDH1A1LMNA | |
| SCHEMBL4873144 | 0.79 | PPARG (0.54) | HRH3PPARGADORA3ALDH1A1LMNA | |
| SCHEMBL14280362 | 0.78 | PPARG (0.56) | HRH3PPARG | |
| SCHEMBL4866928 | 0.77 | PPARA (0.51) | HRH3PPARG | |
| SCHEMBL4873102 | 0.74 | PPARG (0.52) | HRH3PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319170-B2 | N-cyclohexylaminocarbonyl benzensulfonmide derivatives | MERCK & CO., INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319170-B2 | N-cyclohexylaminocarbonyl benzensulfonmide derivatives | MERCK & CO., INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-7319170-B2 | N-cyclohexylaminocarbonyl benzensulfonmide derivatives | MERCK & CO., INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-20060111585-A1 | Title of the invention n-cyclohexylaminocarbonyl benzensulfonmide derivatives | MERCK SHARP & DOHME CORP. | 2006-05-25 | — | — | US | disclosed |
| EP-1587535-A2 | TITLE OF THE INVENTION N-CYCLOHEXYLAMINOCARBONYL BENZENESULFONAMIDE DERIVATIVES | Merck & Co., Inc. (US) | 2005-10-26 | — | — | EP | disclosed |
| WO-2004066963-A2 | N-CYCLOHEXYLAMINOCARBONYL BENZENESULFONAMIDE DERIVATIVES | MERCK & CO., INC. (US) | 2004-08-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060111585-A1 | Title of the invention n-cyclohexylaminocarbonyl benzensulfonmide derivatives | PPARD, PPARA, PPARG | HRH3 2086/4885PPARG 3/4885ADORA3 2410/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.