Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.57 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.57 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.57 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.50 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | AOC3 | Q16853 | 2/20 | 0.47 |
| ▸ | RORC | P51449 | 1/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | XBP1 | P17861 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4990301 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL4990287 | 0.86 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL4874768 | 0.82 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL4874805 | 0.80 | PIK3CD (0.65) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL4863724 | 0.79 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL4863720 | 0.79 | PIK3CD (0.56) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL5547033 | 0.79 | AOC3 (0.50) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL4875817 | 0.79 | PIK3CD (0.60) | PIK3CDPIK3CAPIK3CBPIK3CGALDH1A1 | |
| SCHEMBL5216422 | 0.77 | CA12 (0.67) | ALDH1A1MAPTLMNAPTGS2MEN1 | |
| SCHEMBL5216407 | 0.77 | CA12 (0.67) | ALDH1A1MAPTLMNAPTGS2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442715-B2 | Thiazole derivatives | ASTELLAS PHARMA INC. (JP) | 2008-10-28 | — | — | US | disclosed |
| US-20060276521-A1 | Thiazole derivatives | ASTELLAS PHARMA INC. (JP) | 2006-12-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060276521-A1 | Thiazole derivatives | VCAM1, ICAM1, TXNL1 | PIK3CD 4519/4885PIK3CA 4514/4885PIK3CB 4739/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.