Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 10/20 | 0.73 |
| ▸ | DPP7 | Q9UHL4 | 7/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | DPP8 | Q6V1X1 | 2/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4860587 | 0.87 | DPP4 (0.71) | DPP4DPP7RAB9ASMN1; SMN2NPC1 | |
| SCHEMBL4866908 | 0.85 | DPP4 (1.00) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4869032 | 0.83 | DPP4 (0.78) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4868510 | 0.82 | DPP4 (0.64) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4866005 | 0.79 | DPP4 (0.56) | DPP4DPP7DPP8ALDH1A1KCNH2 | |
| SCHEMBL8297900 | 0.78 | DPP4 (0.44) | DPP4RAB9ASMN1; SMN2NPC1PIK3CG | |
| SCHEMBL4898729 | 0.75 | DPP4 (0.65) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4898736 | 0.75 | DPP4 (0.65) | DPP4DPP7DPP8KCNH2 | |
| SCHEMBL4867798 | 0.72 | DPP4 (0.61) | DPP4DPP7LMNAMAPT | |
| Hydrochloric Acid SCHEMBL1033064 | 0.70 | RAB9A (0.54) | RAB9ASMN1; SMN2NPC1ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7456204-B2 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-7456204-B2 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK & CO., INC. (US) | 2008-11-25 | — | — | US | disclosed |
| US-20070021477-A1 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2007-01-25 | — | — | US | disclosed |
| US-20070021477-A1 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2007-01-25 | — | — | US | disclosed |
| US-20070021477-A1 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | MERCK SHARP & DOHME LLC | 2007-01-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070021477-A1 | Cyclohexylglycine derivatives as dipeptidyl peptidase inhibitors for the treatment or prevention of diabetes | DPP4, DPP3, DPP7 | DPP4 1/4885DPP7 3/4885RAB9A 4544/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.