Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.66 |
| ▸ | F13A1 | P00488 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.56 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.56 |
| ▸ | BLM | P54132 | 1/20 | 0.56 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.52 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10592850 | 0.87 | KDM4E (0.84) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3203944 | 0.85 | KDM4E (0.70) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6845394 | 0.85 | KDM4E (0.70) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL6329536 | 0.85 | KDM4E (0.70) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL3523937 | 0.84 | KDM4E (0.68) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL658361 | 0.81 | KDM4E (0.70) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL14966449 | 0.81 | SMN1; SMN2 (0.68) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL16017577 | 0.81 | PLK1 (0.64) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL10451965 | 0.81 | KDM4E (0.64) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL4867311 | 0.81 | ALDH1A1 (0.73) | KDM4EF13A1SMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008520575-A | — | — | 2008-06-19 | — | — | JP | claimed |
| EP-1812012-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | Ceptyr, Inc. (US) | 2007-08-01 | — | — | EP | claimed |
| WO-2006055525-A2 | PROTEIN TYROSINE PHOSPHATASE INHIBITORS AND METHODS OF USE THEREOF | CEPTYR, INC. (US) | 2006-05-26 | — | — | WO | claimed |