Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 6/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 6/20 | 0.39 |
| ▸ | CA12 | O43570 | 4/20 | 0.38 |
| ▸ | CA9 | Q16790 | 4/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA3 | P07451 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA13 | Q8N1Q1 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | F11 | P03951 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16736421 | 0.72 | CA12 (0.55) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL4664258 | 0.71 | TYMP (0.57) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL4297133 | 0.67 | CA12 (0.50) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL4558727 | 0.64 | KDM4E (0.67) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL37951 | 0.64 | KDM4E (0.67) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL29367508 | 0.64 | KDM4E (0.67) | PDE3BPDE3ACA12CA9CA1 | |
| SCHEMBL29401729 | 0.62 | TYRO3 (0.42) | PDE3BPDE3ACA12CA9KDM4E | |
| Hydrochloric Acid SCHEMBL30832797 | 0.61 | KDM4E (0.63) | PDE3BPDE3ACA12CA9CA1 | |
| Hydrochloric Acid SCHEMBL30275219 | 0.61 | KDM4E (0.63) | PDE3BPDE3ACA12CA9CA1 | |
| Hydrochloric Acid SCHEMBL4647780 | 0.61 | KDM4E (0.63) | PDE3BPDE3ACA12CA9CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2411366-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | Ardea Biosciences, Inc. (US) | 2012-02-01 | — | — | EP | disclosed |
| WO-2010108652-A1 | DIHYDROPYRIDIN SULFONAMIDES AND DIHYDROPYRIDIN SULFAMIDES AS MEK INHIBITORS | ARDEA BIOSCIENCES INC. (US) | 2010-09-30 | — | — | WO | disclosed |