⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1081392 | 1.00 | HRH3 (0.39) | — | |
| SCHEMBL87801 | 1.00 | — | — | |
| Bromide SCHEMBL1471663 | 0.97 | HRH3 (0.38) | — | |
| Ammonia Solution, Strong SCHEMBL1934293 | 0.97 | HRH3 (0.38) | — | |
| Hydrochloric Acid SCHEMBL28067318 | 0.97 | SIGMAR1 (0.39) | — | |
| Bromide SCHEMBL10332289 | 0.97 | HRH3 (0.38) | — | |
| Iodide SCHEMBL28911088 | 0.97 | SMN1; SMN2 (0.38) | — | |
| SCHEMBL88222 | 0.97 | — | — | |
| SCHEMBL1489209 | 0.97 | — | — | |
| Ammonia Solution, Strong SCHEMBL8854910 | 0.94 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 115 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2708541-B1 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis | ISIS PHARMACEUTICALS INC (US) | 2015-01-28 | — | — | EP | claimed |
| EP-2708541-A1 | 5,6-dihydroxy-isoindole derivatives as linkers for oligomer solid phase synthesis | Isis Pharmaceuticals, Inc. (US) | 2014-03-19 | — | — | EP | claimed |
| EP-2465504-A1 | Novel 2,3-diamino-quinazolinone derivatives and their medical use | NeuroSearch A/S (DK) | 2012-06-20 | — | — | EP | claimed |
| US-8178544-B2 | 2, 3-diamino-quinazolinone derivatives and their medical use | NEUROSEARCH A/S (DK) | 2012-05-15 | — | — | US | claimed |
| US-20100160315-A1 | NOVEL 2, 3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE | NEURO SEARCH A/S (DK) | 2010-06-24 | — | — | US | claimed |
| EP-2152272-A2 | NOVEL 2,3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE | NeuroSearch A/S (DK) | 2010-02-17 | — | — | EP | claimed |
| WO-2008142140-A2 | NOVEL 2,3-DIAMINO-QUINAZOLINONE DERIVATIVES AND THEIR MEDICAL USE | NEUROSEARCH A/S (DK) | 2008-11-27 | — | — | WO | claimed |
| CN-101102757-A | Method for the treatment of polycystic kidney disease | WYETH CORP (US) | 2008-01-09 | — | — | CN | claimed |
| CN-1832757-A | Use of a combination of an epidermal growth factor receptor kinase inhibitor and cytotoxic agents for treatment and inhibition of cancer | WYETH CORP (US) | 2006-09-13 | — | — | CN | claimed |
| EP-1692139-A1 | 5,6 -DIHYDROXY-ISOINDOLE DERIVATIVES AS LINKERS FOR OLIGOMER SOLID PHASE SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2006-08-23 | — | — | EP | claimed |
| US-20050159449-A1 | Cannabinoids | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2005-07-21 | — | — | US | claimed |
| WO-2005049621-A1 | 5,6-DIHYDROXY-ISOINDOLE DERIVATIVES AS LINKERS FOR OLIGOMER SOLID PHASE SYNTHESIS | ISIS PHARMACEUTICALS, INC. (US) | 2005-06-02 | — | — | WO | claimed |
| WO-2005028474-A2 | PYRAZOLOQUINOLINE DERIVATIVES AS CHK-1 INHIBITORS | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2005-03-31 | — | — | WO | claimed |
| US-6716856-B1 | CELL PROLIFERATIVE DISORDERS OR ALZHEIMER'S DISEASE; REDUCED TOXICITY; CDK/CYCLIN KINASE INHIBITORY ACTIVITY | PHARMACIA & TUBJOHN SPA (IT) | 2004-04-06 | — | — | US | claimed |
| WO-2003091189-A1 | CANNABINOIDS | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2003-11-06 | — | — | WO | claimed |
| EP-0050286-B1 | GUANIDINE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1985-05-22 | — | — | EP | claimed |
| US-4428935-A | BETA-LACTAMASE INHIBITORS | PFIZER INC. (US) | 1984-01-31 | — | — | US | claimed |
| EP-0063158-A1 | NOVEL GUANIDINE DERIVATIVES | SCHERING CORPORATION (US) | 1982-10-27 | — | — | EP | claimed |
| WO-1982001367-A1 | NOVEL GUANIDINE DERIVATIVES | SCHERING CORP (US) | 1982-04-29 | — | — | WO | claimed |
| EP-0050286-A2 | Guanidine derivatives and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1982-04-28 | — | — | EP | claimed |