Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NUDT14 | O95848 | 2/20 | 0.55 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.55 |
| ▸ | BTK | Q06187 | 14/20 | 0.54 |
| ▸ | EGFR | P00533 | 5/20 | 0.53 |
| ▸ | SRC | P12931 | 2/20 | 0.53 |
| ▸ | LCK | P06239 | 5/20 | 0.50 |
| ▸ | ITK | Q08881 | 4/20 | 0.50 |
| ▸ | JAK3 | P52333 | 2/20 | 0.50 |
| ▸ | LYN | P07948 | 1/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.47 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.47 |
| ▸ | PRKDC | P78527 | 1/20 | 0.47 |
| ▸ | TNK2 | Q07912 | 1/20 | 0.47 |
| ▸ | KIT | P10721 | 1/20 | 0.46 |
| ▸ | FLT3 | P36888 | 1/20 | 0.46 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870460 | 0.89 | NUDT14 (0.56) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL6431415 | 0.88 | SRC (0.58) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL4863506 | 0.87 | NUDT14 (0.54) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL6451355 | 0.86 | BTK (0.54) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL6433095 | 0.86 | NUDT14 (0.57) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL6434937 | 0.84 | NUDT14 (0.55) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL5800505 | 0.81 | SRC (0.63) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL25068862 | 0.81 | NUDT14 (0.68) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL6430984 | 0.81 | NUDT14 (0.55) | NUDT14NUDT5BTKEGFRSRC | |
| SCHEMBL4860031 | 0.79 | BTK (0.56) | NUDT14NUDT5BTKEGFRSRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |