Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BTK | Q06187 | 14/20 | 0.54 |
| ▸ | SRC | P12931 | 9/20 | 0.53 |
| ▸ | EGFR | P00533 | 4/20 | 0.53 |
| ▸ | NUDT14 | O95848 | 2/20 | 0.52 |
| ▸ | NUDT5 | Q9UKK9 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | ABL2 | P42684 | 2/20 | 0.51 |
| ▸ | CSK | P41240 | 2/20 | 0.51 |
| ▸ | CDK1 | P06493 | 1/20 | 0.51 |
| ▸ | LCK | P06239 | 5/20 | 0.49 |
| ▸ | ITK | Q08881 | 2/20 | 0.49 |
| ▸ | JAK3 | P52333 | 1/20 | 0.49 |
| ▸ | LYN | P07948 | 5/20 | 0.48 |
| ▸ | TEK | Q02763 | 1/20 | 0.47 |
| ▸ | FYN | P06241 | 4/20 | 0.46 |
| ▸ | FLT3 | P36888 | 4/20 | 0.46 |
| ▸ | PTK6 | Q13882 | 4/20 | 0.46 |
| ▸ | HCK | P08631 | 3/20 | 0.46 |
| ▸ | FGR | P09769 | 3/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6431415 | 0.94 | SRC (0.58) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL4863506 | 0.89 | NUDT14 (0.54) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL4870460 | 0.87 | NUDT14 (0.56) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL4865119 | 0.86 | NUDT14 (0.55) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL5800505 | 0.85 | SRC (0.63) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL6430984 | 0.82 | NUDT14 (0.55) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL4860031 | 0.81 | BTK (0.56) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL25068862 | 0.79 | NUDT14 (0.68) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL16701418 | 0.79 | BTK (0.67) | BTKSRCEGFRNUDT14NUDT5 | |
| SCHEMBL4820446 | 0.78 | EGFR (0.62) | BTKSRCEGFRNUDT14NUDT5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-7332497-B2 | As inhibitors of protein kinases | ABBOTT GMBH & CO KG (DE) | 2008-02-19 | — | — | US | disclosed |
| US-6921763-B2 | Pyrazolopyrimidines as therapeutic agents | ABBOTT LABORATORIES (US) | 2005-07-26 | — | — | US | disclosed |