Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 8/20 | 0.87 |
| ▸ | CYP3A4 | P08684 | 8/20 | 0.87 |
| ▸ | CYP2D6 | P10635 | 8/20 | 0.87 |
| ▸ | CYP2C19 | P33261 | 8/20 | 0.87 |
| ▸ | TSHR | P16473 | 7/20 | 0.87 |
| ▸ | USP2 | O75604 | 5/20 | 0.87 |
| ▸ | LMNA | P02545 | 4/20 | 0.87 |
| ▸ | CLK4 | Q9HAZ1 | 4/20 | 0.87 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.87 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.87 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.87 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.87 |
| ▸ | MAPT | P10636 | 2/20 | 0.82 |
| ▸ | MEN1 | O00255 | 8/20 | 0.75 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.75 |
| ▸ | APP | P05067 | 1/20 | 0.73 |
| ▸ | PDE5A | O76074 | 4/20 | 0.70 |
| ▸ | GBA1 | P04062 | 1/20 | 0.70 |
| ▸ | ATM | Q13315 | 1/20 | 0.70 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4863831 | 0.92 | CYP1A2 (0.74) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4867805 | 0.90 | CYP1A2 (0.74) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4859116 | 0.88 | CYP1A2 (0.72) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL12176088 | 0.86 | LMNA (0.76) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL2587104 | 0.85 | APP (0.76) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4867976 | 0.85 | APP (0.76) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL3108468 | 0.84 | APP (0.74) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL12176090 | 0.84 | LMNA (0.72) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL1083760 | 0.83 | MEN1 (1.00) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR | |
| SCHEMBL4866326 | 0.83 | APP (0.73) | CYP1A2CYP3A4CYP2D6CYP2C19TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | claimed |
| JP-2008526734-A | — | — | 2008-07-24 | — | — | JP | claimed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | claimed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | claimed |
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2008-08-28 | — | — | US | disclosed |
| EP-1844023-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2007-10-17 | — | — | EP | disclosed |
| WO-2006071095-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | SK CHEMICALS CO., LTD. (KR) | 2006-07-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080207614-A1 | QUINAZOLINE DERIVATIVES FOR THE TREATMENT AND PREVENTION OF DIABETES AND OBESITY | GPR119, GCKR, GLP1R | CYP1A2 528/4885CYP3A4 441/4885CYP2D6 1681/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.