Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | MPL | P40238 | 2/20 | 0.50 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | BCR | P11274 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
| ▸ | AURKA | O14965 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.43 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868204 | 0.86 | SMN1; SMN2 (0.50) | SMN1; SMN2RAB9AALDH1A1MPLABL1 | |
| SCHEMBL8798290 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2RAB9AALDH1A1ABL1BCR | |
| SCHEMBL31660945 | 0.79 | SMN1; SMN2 (0.61) | SMN1; SMN2RAB9AALDH1A1ABL1BCR | |
| SCHEMBL14421264 | 0.78 | CD274 (0.55) | SMN1; SMN2RAB9AALDH1A1ABL1BCR | |
| SCHEMBL27741343 | 0.78 | CD274 (0.55) | SMN1; SMN2RAB9AALDH1A1ABL1BCR | |
| SCHEMBL4724653 | 0.75 | NPC1 (0.55) | SMN1; SMN2RAB9ANPC1EGFRERBB3 | |
| SCHEMBL4872523 | 0.75 | NPC1 (0.57) | SMN1; SMN2RAB9ANPC1EGFRERBB3 | |
| SCHEMBL5244511 | 0.73 | NPC1 (0.56) | SMN1; SMN2RAB9ANPC1EGFRERBB3 | |
| SCHEMBL27401069 | 0.73 | KMO (0.52) | SMN1; SMN2RAB9AALDH1A1ABL1BCR | |
| SCHEMBL31660951 | 0.72 | CD274 (0.51) | SMN1; SMN2RAB9AALDH1A1ABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | REITER LAWRENCE A | 2008-03-27 | — | — | US | disclosed |
| EP-1794156-A2 | TROMBOPOIETIN RECEPTOR AGONISTS | Pfizer Products Incorporated (US) | 2007-06-13 | — | — | EP | disclosed |
| WO-2006033005-A2 | THROMBOPOIETIN RECEPTOR AGONISTS | PFIZER PRODUCTS INC. (US) | 2006-03-30 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080076771-A1 | Thrombopoietin Receptor Agonists | MPL, THPO, TBXA2R | SMN1; SMN2 3733/4885RAB9A 2219/4885ALDH1A1 2423/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.