Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTK2 | Q05397 | 1/20 | 0.54 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.54 |
| ▸ | FLT3 | P36888 | 2/20 | 0.51 |
| ▸ | PI4KA | P42356 | 6/20 | 0.49 |
| ▸ | PI4K2B | Q8TCG2 | 6/20 | 0.49 |
| ▸ | PI4K2A | Q9BTU6 | 6/20 | 0.49 |
| ▸ | PI4KB | Q9UBF8 | 6/20 | 0.49 |
| ▸ | KDR | P35968 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 4/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.46 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4868939 | 0.87 | KDR (0.61) | PTK2PTK2BFLT3KDRBRAF | |
| SCHEMBL3836444 | 0.83 | FLT3 (0.49) | PTK2FLT3KDRBRAFMAPK14 | |
| SCHEMBL14191791 | 0.81 | PTK2 (0.60) | PTK2PTK2BFLT3PI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL5111052 | 0.81 | PTK2 (0.59) | PTK2PTK2BFLT3PI4KAPI4K2B | |
| SCHEMBL5437698 | 0.80 | FLT3 (0.49) | FLT3KDRBRAFAURKAAURKB | |
| SCHEMBL5105069 | 0.80 | RIPK1 (0.58) | PTK2PTK2BFLT3PI4KAPI4K2B | |
| SCHEMBL4875351 | 0.80 | PTK2 (0.56) | PTK2PTK2BFLT3PI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL5106721 | 0.79 | RIPK1 (0.57) | PTK2PTK2BFLT3PI4KAPI4K2B | |
| SCHEMBL14191847 | 0.79 | PTK2 (0.56) | PTK2PTK2BFLT3PI4KAPI4K2B | |
| Hydrochloric Acid SCHEMBL5111961 | 0.79 | PTK2 (0.55) | PTK2PTK2BFLT3PI4KAPI4K2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-09-04 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | TIE1, FLT1, RET | PTK2 869/4885PTK2B 68/4885FLT3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.