Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | KDR | P35968 | 3/20 | 0.48 |
| ▸ | AURKA | O14965 | 1/20 | 0.48 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 3/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | EPHA3 | P29320 | 1/20 | 0.44 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 3/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5436578 | 0.86 | KDR (0.64) | FLT3KDRAURKAAURKBBRAF | |
| SCHEMBL5447368 | 0.81 | KDR (0.52) | FLT3KDRAURKAAURKBKMT2A | |
| SCHEMBL5440835 | 0.81 | KDR (0.53) | FLT3KDRAURKAAURKBBRAF | |
| SCHEMBL5447759 | 0.81 | EPHA3 (0.47) | FLT3KDRBRAFEPHX2MEN1 | |
| SCHEMBL4865620 | 0.80 | PTK2 (0.54) | FLT3KDRAURKAAURKBBRAF | |
| SCHEMBL27673027 | 0.80 | KDR (0.44) | FLT3KDRAURKAAURKBEPHA3 | |
| SCHEMBL5449198 | 0.79 | CDK8 (0.53) | FLT3KDRAURKAAURKBBRAF | |
| SCHEMBL27673022 | 0.79 | KDR (0.41) | KDRAURKAAURKBEPHX2TP53 | |
| SCHEMBL5440797 | 0.78 | KDR (0.57) | KDRCDK8 | |
| SCHEMBL5440740 | 0.77 | RIPK1 (0.51) | KDRAURKAAURKBBRAFEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | MERCK PATENT GMBH (DE) | 2007-09-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070225347-A1 | Imidazole Derivatives | TIE1, FLT1, FER | FLT3 7/4885KDR 4/4885AURKA 302/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.