Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 13/20 | 0.47 |
| ▸ | HTR2C | P28335 | 5/20 | 0.47 |
| ▸ | HTR2B | P41595 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR1D | P28221 | 2/20 | 0.47 |
| ▸ | HTR1B | P28222 | 2/20 | 0.47 |
| ▸ | HTR7 | P34969 | 2/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.41 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.41 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.41 |
| ▸ | FADS1 | O60427 | 1/20 | 0.39 |
| ▸ | WNT3 | P56703 | 1/20 | 0.39 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3853169 | 0.90 | HTR2C (0.53) | HTR6HTR2CHTR2BWNT3SFRP1 | |
| SCHEMBL3857911 | 0.83 | HTR6 (0.55) | HTR6HTR2CHTR2BWNT3SFRP1 | |
| SCHEMBL3844022 | 0.76 | HTR6 (0.54) | HTR6HTR2CHTR2BCYP3A4 | |
| SCHEMBL1012930 | 0.72 | HTR6 (0.56) | HTR6 | |
| SCHEMBL13989700 | 0.71 | HTR2C (0.55) | HTR6HTR2CHTR2BHTR1B | |
| SCHEMBL5690967 | 0.71 | PDPK1 (0.54) | HTR6HTR2CHTR1BFADS1CA1 | |
| Hydrochloric Acid SCHEMBL4901126 | 0.70 | HTR2C (0.54) | HTR6HTR2CHTR2BHTR1AHTR1D | |
| SCHEMBL14437278 | 0.70 | CNR1 (0.49) | HTR6HTR2BPDE4APDE4BPDE4C | |
| SCHEMBL27752358 | 0.68 | HTR6 (0.58) | HTR6 | |
| SCHEMBL315805 | 0.68 | HTR6 (0.80) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2008524274-A | — | — | 2008-07-10 | — | — | JP | claimed |
| EP-1831189-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | F. Hoffmann-Roche AG (CH) | 2007-09-12 | — | — | EP | claimed |
| WO-2006066745-A1 | TETRALIN AND INDANE DERIVATIVES AND USES THEREOF | F.HOFFMANN-LA ROCHE AG (CH) | 2006-06-29 | — | — | WO | claimed |