Known targets — ChEMBL curated mechanism
MMP1MMP13MMP7MMP8polrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Alcohol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CES2 | O00748 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | STAT3 | P40763 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.31 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 3/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | CNR1 | P21554 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21903093 | 0.93 | LMNA (0.46) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL4859375 | 0.93 | LMNA (0.46) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL21963798 | 0.93 | LMNA (0.46) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL4862343 | 0.93 | LMNA (0.46) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL11457314 | 0.83 | LMNA (0.46) | LMNAMEN1CYP3A4ALOX15MAPK1 | |
| SCHEMBL11457315 | 0.83 | LMNA (0.46) | LMNAMEN1CYP3A4ALOX15MAPK1 | |
| Fumaric Acid SCHEMBL10486731 | 0.80 | LMNA (0.37) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL1617981 | 0.73 | LMNA (0.46) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL12746227 | 0.73 | LMNA (0.46) | LMNACES2MEN1CYP3A4ALOX15 | |
| SCHEMBL27183023 | 0.71 | ALOX15 (0.60) | LMNAMEN1CYP3A4ALOX15MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080312465-A1 | INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DRONABINOL | ALPHORA RESEARCH INC. (CA) | 2008-12-18 | — | — | US | disclosed |
| US-7323576-B2 | Synthetic route to dronabinol | ALPHORA RESEARCH INC. (CA) | 2008-01-29 | — | — | US | disclosed |
| US-20060074252-A1 | Synthetic route to dronabinol | SANDOZ INC. | 2006-04-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080312465-A1 | INTERMEDIATE COMPOUNDS IN THE SYNTHESIS OF DRONABINOL | CNR1, CNR2, CYP8B1 | LMNA 2589/4885CES2 454/4885MEN1 669/4885 |
| US-20060074252-A1 | Synthetic route to dronabinol | CNR1, CNR2, CYP8B1 | LMNA 3551/4885CES2 690/4885MEN1 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.