Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 16/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 12/20 | 0.49 |
| ▸ | ADORA1 | P30542 | 12/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | PCK1 | P35558 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859051 | 0.95 | ADORA2B (0.55) | ADORA2BADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL4867559 | 0.95 | ADORA2B (0.49) | ADORA2BADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL4866175 | 0.94 | ADORA2B (0.54) | ADORA2BADORA2AADORA1ALDH1A1PCK1 | |
| SCHEMBL4859057 | 0.91 | ADORA2B (0.46) | ADORA2BADORA2AADORA1ALDH1A1HTT | |
| SCHEMBL4885090 | 0.90 | ADORA2B (0.51) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL4862662 | 0.89 | ADORA2B (0.49) | ADORA2BADORA2AADORA1PCK1ADORA3 | |
| SCHEMBL4866176 | 0.87 | ADORA2B (0.49) | ADORA2BADORA2AADORA1ALDH1A1PCK1 | |
| SCHEMBL4860861 | 0.86 | ADORA2B (0.59) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL4890388 | 0.85 | ADORA2B (0.57) | ADORA2BADORA2AADORA1ADORA3 | |
| SCHEMBL4763211 | 0.84 | ADORA2B (0.42) | ADORA2BADORA2AADORA1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7449473-B2 | Substituted pyrrolo[3,2-d]pyrimidin-2,4-diones as A2b adenosine receptor antagonists | CV THERAPEUTICS, INC. (US) | 2008-11-11 | — | — | US | disclosed |
| US-20050119287-A1 | A2B adenosine receptor antagonists | GILEAD PALO ALTO, INC. | 2005-06-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050119287-A1 | A2B adenosine receptor antagonists | ADORA2B, ADORA2A, ADORA3 | ADORA2B 1/4885ADORA2A 2/4885ADORA1 4/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.