Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 8/20 | 0.50 |
| ▸ | HTR2A | P28223 | 8/20 | 0.50 |
| ▸ | DRD3 | P35462 | 8/20 | 0.50 |
| ▸ | SCN9A | Q15858 | 7/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.48 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.47 |
| ▸ | SMYD3 | Q9H7B4 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866636 | 1.00 | DRD2 (0.50) | DRD2HTR2ADRD3SCN9AKCNH2 | |
| SCHEMBL4750025 | 0.84 | SCN9A (0.65) | HTR2ADRD3SCN9AKCNH2SCN5A | |
| SCHEMBL4750963 | 0.84 | SCN9A (0.51) | SCN9AKCNH2SCN5ANPC1RAB9A | |
| SCHEMBL4750039 | 0.83 | SCN9A (0.66) | HTR2ADRD3SCN9AKCNH2SCN5A | |
| SCHEMBL4747610 | 0.81 | SCN9A (0.52) | SCN9AKCNH2SCN5A | |
| SCHEMBL4838400 | 0.81 | KCNH2 (0.70) | DRD2HTR2ADRD3SCN9AKCNH2 | |
| SCHEMBL4838380 | 0.81 | KCNH2 (0.70) | DRD2HTR2ADRD3SCN9AKCNH2 | |
| SCHEMBL4749784 | 0.78 | SCN9A (0.41) | DRD2HTR2ADRD3SCN9AKCNH2 | |
| SCHEMBL4750462 | 0.78 | SCN9A (0.53) | DRD2HTR2ADRD3SCN9AKCNH2 | |
| SCHEMBL4749667 | 0.77 | SCN9A (0.42) | DRD2HTR2ADRD3SCN9AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | claimed |
| WO-2008130319-A2 | NOVEL N-TETRAHYDRONAPHTALENE OR N-CHROMANE CARBOXAMIDE DERIVATIVES FOR THE TREATMENT OF PAIN | ASTRAZENECA AB (SE) | 2008-10-30 | — | — | WO | disclosed |