Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
| ▸ | JAK3 | P52333 | 1/20 | 0.43 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.41 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.41 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.41 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.41 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.41 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | SMARCA2 | P51531 | 2/20 | 0.40 |
| ▸ | SMARCA4 | P51532 | 2/20 | 0.40 |
| ▸ | PBRM1 | Q86U86 | 2/20 | 0.40 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.40 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.39 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | CSF1R | P07333 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4865463 | 1.00 | JAK1 (0.43) | JAK1JAK3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4865454 | 1.00 | JAK1 (0.43) | JAK1JAK3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4865461 | 1.00 | JAK1 (0.43) | JAK1JAK3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6220849 | 1.00 | JAK1 (0.43) | JAK1JAK3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL4866890 | 1.00 | JAK1 (0.43) | JAK1JAK3GRIN2DGRIN3BGRIN1 | |
| SCHEMBL3950324 | 0.80 | JAK3 (0.48) | JAK3GRIN2DGRIN3BGRIN1GRIN2A | |
| SCHEMBL20336407 | 0.73 | ALDH1A1 (0.42) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL22587517 | 0.73 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL29445489 | 0.73 | GRIN2D (0.48) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B | |
| SCHEMBL2825683 | 0.70 | HRH3 (0.51) | GRIN2DGRIN3BGRIN1GRIN2AGRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7361662-B2 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same | LES LABORATOIRES SERVIER (FR) | 2008-04-22 | — | — | US | disclosed |
| EP-1560826-B1 | PYRIDOPYRIMIDINONE COMPOUNDS, METHOD FOR PRODUCTION THEREOF AND MEDICAMENTS COMPRISING THE SAME | SERVIER LAB (FR) | 2006-04-12 | — | — | EP | disclosed |
| US-20050288311-A1 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same | LES LABORATOIERS SERVIER (FR) | 2005-12-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050288311-A1 | Pyridopyrimidinone compounds, method for production thereof and medicaments comprising the same | MAP4K2, PLK2, MAP4K3 | JAK1 10/4885JAK3 40/4885GRIN2D 1759/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.