Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AHCY | P23526 | 13/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | HSP90B1 | P14625 | 2/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.46 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.46 |
| ▸ | PRMT9 | Q6P2P2 | 1/20 | 0.46 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.46 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.46 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.46 |
| ▸ | PRMT8 | Q9NR22 | 1/20 | 0.46 |
| ▸ | PRMT7 | Q9NVM4 | 1/20 | 0.46 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869572 | 0.90 | AHCY (0.51) | AHCYADORA2AHSP90B1ADORA3HSP90AA1 | |
| SCHEMBL4865596 | 0.88 | AHCY (0.51) | AHCYHIF1ATMEM97SIGMAR1ADORA2A | |
| SCHEMBL8285526 | 0.88 | AHCY (0.51) | AHCYHIF1ATMEM97SIGMAR1ADORA2A | |
| SCHEMBL14279857 | 0.88 | AHCY (0.51) | AHCYADORA2AHSP90B1ADORA3HSP90AA1 | |
| SCHEMBL14279835 | 0.88 | AHCY (0.51) | AHCYHIF1ATMEM97SIGMAR1ADORA2A | |
| SCHEMBL4867938 | 0.88 | AHCY (0.51) | AHCYADORA2AHSP90B1ADORA3HSP90AA1 | |
| SCHEMBL4867945 | 0.88 | AHCY (0.51) | AHCYADORA2AHSP90B1ADORA3HSP90AA1 | |
| SCHEMBL4867397 | 0.88 | AHCY (0.51) | AHCYADORA2AHSP90B1ADORA3HSP90AA1 | |
| SCHEMBL4868847 | 0.88 | AHCY (0.51) | AHCYHIF1ATMEM97SIGMAR1ADORA2A | |
| SCHEMBL4868820 | 0.88 | AHCY (0.51) | AHCYHIF1ATMEM97SIGMAR1ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7319101-B2 | COMT inhibitors for the treatment of depression and impaired cognition | HOFFMANN-LA ROCHE INC. (US) | 2008-01-15 | — | — | US | disclosed |
| US-20050137162-A1 | New COMT inhibitors for the treatment of depression and impaired cognition | F. HOFFMANN-LA ROCHE AG (CH) | 2005-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050137162-A1 | New COMT inhibitors for the treatment of depression and impaired cognition | COMT, MAOB, TPH1 | AHCY 814/4885HIF1A 1034/4885TMEM97 3229/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.