Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 5/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | ACACA | Q13085 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4873749 | 0.85 | MAPK14 (0.44) | MAPTNPC1RAB9AKDM4EALDH1A1 | |
| SCHEMBL4872629 | 0.85 | THRB (0.56) | MAPTNPC1RAB9AKDM4EMAPK1 | |
| SCHEMBL4862130 | 0.82 | TGFBR1 (0.53) | KDM4EMAPK1MAPK14THRBTGFBR1 | |
| SCHEMBL4873701 | 0.82 | AKT1 (0.46) | MAPK1MAPK14THRBTGFBR1 | |
| SCHEMBL4872673 | 0.81 | JAK2 (0.42) | MAPK14THRBTGFBR1L3MBTL1 | |
| SCHEMBL4872814 | 0.81 | MAPK14 (0.45) | MAPK1MAPK14THRBTGFBR1 | |
| SCHEMBL4872159 | 0.80 | TGFBR1 (0.55) | MAPTALDH1A1HSD17B10HPGDMAPK14 | |
| SCHEMBL4865628 | 0.80 | MAPK14 (0.44) | NPC1RAB9AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL4868119 | 0.80 | MAPK14 (0.60) | MAPK14THRBTGFBR1 | |
| SCHEMBL4867464 | 0.79 | MAPK14 (0.46) | MAPK1MAPK14THRBTGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |