Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | BDKRB1 | P46663 | 8/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.35 |
| ▸ | PSEN1 | P49768 | 3/20 | 0.34 |
| ▸ | PSEN2 | P49810 | 3/20 | 0.34 |
| ▸ | APH1B | Q8WW43 | 3/20 | 0.34 |
| ▸ | NCSTN | Q92542 | 3/20 | 0.34 |
| ▸ | APH1A | Q96BI3 | 3/20 | 0.34 |
| ▸ | PSENEN | Q9NZ42 | 3/20 | 0.34 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4869904 | 0.93 | ALDH1A1 (0.41) | ALDH1A1POLBBDKRB1KMT2ATP53 | |
| SCHEMBL4871674 | 0.91 | ALDH1A1 (0.42) | ALDH1A1POLBBDKRB1KMT2ATP53 | |
| SCHEMBL4867664 | 0.82 | ALDH1A1 (0.44) | ALDH1A1POLBKMT2ATP53LMNA | |
| SCHEMBL4870251 | 0.81 | ALDH1A1 (0.47) | ALDH1A1POLBBDKRB1KMT2ATP53 | |
| SCHEMBL4871094 | 0.80 | KMT2A (0.45) | ALDH1A1POLBBDKRB1KMT2ATP53 | |
| SCHEMBL4864117 | 0.80 | ALDH1A1 (0.44) | ALDH1A1POLBBDKRB1KMT2ATP53 | |
| SCHEMBL4867868 | 0.74 | ALDH1A1 (0.44) | ALDH1A1POLBBDKRB1KMT2ATP53 | |
| SCHEMBL4158564 | 0.73 | KMT2A (0.48) | KMT2A | |
| SCHEMBL4496382 | 0.70 | MMP8 (0.40) | ALDH1A1POLBKMT2ATP53PSEN1 | |
| SCHEMBL4511409 | 0.70 | MMP8 (0.40) | ALDH1A1POLBKMT2ATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7351709-B2 | Estrogen receptor ligands | WYETH (US) | 2008-04-01 | — | — | US | disclosed |
| US-20060019961-A1 | Estrogen receptor ligands | WYETH | 2006-01-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060019961-A1 | Estrogen receptor ligands | GPER1, ESR2, ESR1 | ALDH1A1 1051/4885POLB 4581/4885BDKRB1 164/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.