Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | THRB | P10828 | 1/20 | 0.54 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4867471 | 0.82 | TP53 (0.81) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL4868227 | 0.82 | POLB (0.60) | POLBLMNAMAPTSMN1; SMN2THRB | |
| SCHEMBL4869023 | 0.81 | TP53 (0.78) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL4870223 | 0.81 | TP53 (0.57) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL4870873 | 0.77 | POLB (0.61) | POLBLMNAMAPTTP53THRB | |
| SCHEMBL4868334 | 0.75 | POLB (0.59) | POLBLMNAMAPTTP53SMN1; SMN2 | |
| SCHEMBL4863126 | 0.75 | POLB (0.83) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL4869602 | 0.75 | MAPT (0.71) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL4868688 | 0.74 | LMNA (0.53) | POLBLMNAMAPTTP53NPC1 | |
| SCHEMBL4865198 | 0.74 | MAPT (0.70) | POLBLMNAMAPTTP53NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7368444-B2 | N-carbamoyl nitrogen-containing fused ring compounds and drugs containing these compounds as the active ingredient | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-05-06 | — | — | US | claimed |