Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | SCN1A | P35498 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.40 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.40 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25795138 | 0.93 | SMN1; SMN2 (0.43) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL18410958 | 0.85 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL19506954 | 0.85 | ALDH1A1 (0.40) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL19888347 | 0.83 | SMN1; SMN2 (0.47) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL21015244 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL8282663 | 0.82 | SMN1; SMN2 (0.54) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL19506630 | 0.81 | CNR1 (0.41) | SMN1; SMN2SIGMAR1CYP1A2ALDH1A1MAPK1 | |
| SCHEMBL19261397 | 0.81 | CNR1 (0.41) | SMN1; SMN2SIGMAR1CYP1A2ALDH1A1MAPK1 | |
| SCHEMBL19633992 | 0.80 | ALDH1A1 (0.38) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL23471274 | 0.79 | SMN1; SMN2 (0.47) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7320992-B2 | Substituted 2,3-dihydro-1h-isoindol-1-one derivatives and methods of use | AMGEN INC. (US) | 2008-01-22 | — | — | US | claimed |
| EP-1971604-B1 | PYRROLO-PYRIDINE DERIVATIVES FOR THE TREATMENT OF CANCER DISEASES | AMGEN INC (US) | 2012-08-01 | — | — | EP | disclosed |