Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | SCN1A | P35498 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.36 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4870940 | 0.93 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL8282663 | 0.80 | SMN1; SMN2 (0.54) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL179555 | 0.80 | ALDH1A1 (0.41) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL23179815 | 0.79 | SMN1; SMN2 (0.46) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL18410958 | 0.79 | SMN1; SMN2 (0.48) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL19506954 | 0.79 | ALDH1A1 (0.40) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL25795246 | 0.79 | MAOB (0.38) | SIGMAR1 | |
| SCHEMBL15183488 | 0.78 | CHRM4 (0.35) | CHRM2CHRM1HRH3PAOX | |
| SCHEMBL19888347 | 0.77 | SMN1; SMN2 (0.47) | SMN1; SMN2KEAP1SIGMAR1CYP2D6CYP1A2 | |
| SCHEMBL21016295 | 0.77 | CHRM4 (0.33) | CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | Halia Therapeutics, Inc. | 2023-07-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230210853-A1 | TARGETED NEK7 INHIBITION FOR MODULATION OF THE NLRP3 INFLAMMASOME | NEK7, NLRP3, NOD1 | SMN1; SMN2 3670/4885KEAP1 293/4885SIGMAR1 4107/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.