Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 5/20 | 0.33 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.32 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.30 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.30 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4871144 | 1.00 | NPC1 (0.34) | NPC1RAB9APKMMAPK14POLB | |
| SCHEMBL4873533 | 0.87 | CHRNA7 (0.34) | NPC1RAB9AMAPK14CHRNA7L3MBTL1 | |
| SCHEMBL4873528 | 0.87 | CHRNA7 (0.34) | NPC1RAB9AMAPK14CHRNA7L3MBTL1 | |
| SCHEMBL5182329 | 0.86 | MAPK14 (0.35) | NPC1RAB9AMAPK14CHRNA7MAPK13 | |
| SCHEMBL5182325 | 0.86 | MAPK14 (0.35) | NPC1RAB9AMAPK14CHRNA7MAPK13 | |
| SCHEMBL4873178 | 0.84 | MAPK14 (0.35) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4873184 | 0.84 | MAPK14 (0.35) | MAPK14MAPK13MAPK12MAPK11 | |
| SCHEMBL4879567 | 0.84 | MAPK14 (0.35) | RAB9AMAPK14CHRNA7L3MBTL1MAPK13 | |
| SCHEMBL4879572 | 0.84 | MAPK14 (0.35) | RAB9AMAPK14CHRNA7L3MBTL1MAPK13 | |
| SCHEMBL4879615 | 0.84 | MAPK14 (0.34) | MAPK14CHRNA7MAPK13MAPK12MAPK11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080081825-A1 | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof | ONO PHARMACEUTICAL CO., LTD. (JP) | 2008-04-03 | — | — | US | disclosed |
| EP-1741702-A1 | NITROGEN-CONTAINING HETEROCYCLIC COMPOUNDS AND MEDICINAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2007-01-10 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080081825-A1 | Nitrogen-Containing Heterocyclic Compounds and Medicinal Use Thereof | MAPK1, NOS1, NOS2 | NPC1 1526/4885RAB9A 1257/4885PKM 783/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.