Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | MEN1 | O00255 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.52 |
| ▸ | NPC1 | O15118 | 4/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.52 |
| ▸ | MAPT | P10636 | 3/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | TNNI3 | P19429 | 1/20 | 0.52 |
| ▸ | TNNT2 | P45379 | 1/20 | 0.52 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.52 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.52 |
| ▸ | CBFB | Q13951 | 1/20 | 0.52 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4742392 | 0.77 | BACE1 (0.46) | MEN1KMT2AADORA3GPBAR1ERN1 | |
| SCHEMBL4740926 | 0.76 | GPBAR1 (0.59) | KDM4EKMT2ANPC1ALDH1A1GPBAR1 | |
| SCHEMBL4740931 | 0.74 | GPBAR1 (0.73) | GPBAR1 | |
| SCHEMBL4741461 | 0.73 | ERN1 (0.48) | MAPTMAPK8MAPK9ALDH1A1SMN1; SMN2 | |
| SCHEMBL3262682 | 0.72 | CSNK2A2 (0.46) | NPC1GPBAR1ERN1 | |
| SCHEMBL4739252 | 0.71 | GPBAR1 (0.55) | POLBGPBAR1ERN1 | |
| SCHEMBL18075701 | 0.71 | KDM4E (1.00) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL14384586 | 0.69 | CNR1 (0.64) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL222027 | 0.68 | SMN1; SMN2 (0.68) | KDM4EMEN1KMT2ANPC1RAB9A | |
| SCHEMBL29950917 | 0.68 | RAB9A (0.59) | KDM4EMEN1KMT2ANPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080221161-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| US-20080221161-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| US-20080221161-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| WO-2008097976-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | KALYPSYS, INC. (US) | 2008-08-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080221161-A1 | HETEROCYCLIC MODULATORS OF TGR5 FOR TREATMENT OF DISEASE | GPR119, GPBAR1, LDLR | KDM4E 3744/4885MEN1 4772/4885KMT2A 4224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.