Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TTR | P02766 | 2/20 | 0.42 |
| ▸ | VCAM1 | P19320 | 1/20 | 0.42 |
| ▸ | CASP6 | P55212 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27352241 | 0.98 | GPR35 (0.52) | GPR35TDP1TSHRMAPK1ATM | |
| SCHEMBL34473568 | 0.85 | TDP1 (0.52) | GPR35TDP1TSHRMAPK1ATM | |
| SCHEMBL29940081 | 0.82 | TDP1 (0.63) | GPR35TDP1TSHRMAPK1ATM | |
| SCHEMBL2551163 | 0.82 | TDP1 (0.63) | GPR35TDP1TSHRMAPK1ATM | |
| SCHEMBL10434405 | 0.80 | GPR35 (0.57) | GPR35TDP1TSHRMAPK1HIF1A | |
| SCHEMBL31170798 | 0.80 | TDP1 (0.67) | GPR35TDP1TSHRMAPK1ALDH1A1 | |
| SCHEMBL5595026 | 0.80 | TDP1 (0.67) | GPR35TDP1TSHRMAPK1ALDH1A1 | |
| SCHEMBL308086 | 0.80 | TDP1 (0.50) | GPR35TDP1TSHRMAPK1ATM | |
| SCHEMBL521166 | 0.80 | GPR35 (0.54) | GPR35TDP1TSHRMAPK1ATM | |
| SCHEMBL29705108 | 0.80 | TDP1 (0.50) | GPR35TDP1TSHRMAPK1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-11279100-A | — | — | None | — | — | JP | disclosed |
| CN-118852123-A | Novel heterocyclic compounds as Pol theta inhibitors for the treatment and prevention of cancer and pharmaceutical compositions containing the same | 株式会社大熊制药 | 2024-10-29 | — | — | CN | disclosed |
| US-20240307362-A1 | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2024-09-19 | — | — | US | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| WO-2023144793-A1 | POL THETA INHIBITORS | RHIZEN PHARMACEUTICALS AG (CH) | 2023-08-03 | — | — | WO | disclosed |
| EP-3959212-A1 | 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS | Bayer Aktiengesellschaft (DE) | 2022-03-02 | — | — | EP | disclosed |
| WO-2020216773-A1 | 4H-PYRROLO[3,2-C]PYRIDIN-4-ONE COMPOUNDS | BAYER AKTIENGESELLSCHAFT (DE) | 2020-10-29 | — | — | WO | disclosed |
| US-7408067-B2 | Aza-cyclic compounds as modulators of acetylcholine receptors | MERCK + CO., INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20070054912-A1 | Modulators of acetylcholine receptors | ASTLES PETER C | 2007-03-08 | — | — | US | disclosed |
| US-7148236-B2 | Modulators of acetylcholine receptors | MERCK & CO., INC. (US) | 2006-12-12 | — | — | US | disclosed |
| EP-1472248-A1 | MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-11-03 | — | — | EP | disclosed |
| EP-1467986-A1 | AZA-CYCLIC COMPOUNDS AS MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2004-10-20 | — | — | EP | disclosed |
| WO-2003062224-A1 | AZA-CYCLIC COMPOUNDS AS MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2003-07-31 | — | — | WO | disclosed |
| WO-2003062235-A1 | MODULATORS OF ACETYLCHOLINE RECEPTORS | ELI LILLY AND COMPANY (US) | 2003-07-31 | — | — | WO | disclosed |
| US-6172268-B1 | REACTING A HYDROXY AROMATIC COMPOUND WITH A PROPYLENE OXIDE IN PRESENCE OF METAL COMPLEX CATALYST | ASAHI GLASS COMPANY, LIMITED (JP) | 2001-01-09 | — | — | US | disclosed |
| JP-H11279100-A | PRODUCTION OF OPTICALLY ACTIVE 1-SUBSTITUTED-2-PROPANOL | ASAHI GLASS CO LTD | 1999-10-12 | — | — | JP | disclosed |
| US-5773651-A | Process for the preparation of fluorine-containing chemical compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-06-30 | — | — | US | disclosed |
| EP-0778081-A1 | Process for preparing fluorine containing chemical compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-06-11 | — | — | EP | disclosed |
| CN-1042538-A | Opticity benzoxazine and benzothiazine and Stereoselective preparation method thereof | GIST BROCADES NV (NL) | 1990-05-30 | — | — | CN | disclosed |
| EP-0368410-A2 | Optically active benzoxazines and bezothiazines and a process for their stereospecific preparation | GIST-BROCADES N.V. (NL) | 1990-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240307362-A1 | 4H-PYRROLO[3,2-c]PYRIDIN-4-ONE COMPOUNDS | CYP4B1, CYP2C19, CYP3A4 | GPR35 3962/4885TDP1 2655/4885TSHR 1782/4885 |
| US-20070054912-A1 | Modulators of acetylcholine receptors | CHRM3, CHRNG, CHRM5 | GPR35 170/4885TDP1 1721/4885TSHR 82/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.