Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 7/20 | 0.47 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3584269 | 0.85 | GRIN2B (0.40) | MAPTLMNASMN1; SMN2POLBGRIN2B | |
| SCHEMBL3581616 | 0.85 | MAPK1 (0.41) | MAPTLMNASMN1; SMN2 | |
| SCHEMBL3576053 | 0.84 | PIN1 (0.43) | ALDH1A1LMNAHTTSMN1; SMN2KDM4E | |
| SCHEMBL3579063 | 0.83 | GRIN2B (0.34) | MAPTLMNASMN1; SMN2TLR7POLB | |
| SCHEMBL3588606 | 0.83 | CPT1A (0.44) | — | |
| SCHEMBL14496017 | 0.82 | CPT1A (0.39) | ALDH1A1KDM4ETLR7 | |
| SCHEMBL3587868 | 0.82 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ASMN1; SMN2TLR7 | |
| SCHEMBL3591786 | 0.81 | CPT1A (0.37) | ALDH1A1HTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL3589486 | 0.80 | GRIN2B (0.43) | ALDH1A1HTTMEN1KMT2AKDM4E | |
| SCHEMBL3581033 | 0.80 | TP53 (0.36) | MAPTLMNAHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1962605-A2 | 2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | Merck & Co., Inc. (US) | 2008-09-03 | — | — | EP | disclosed |
| WO-2007070433-A2 | 2-ARYLTHIAZOLE DERIVATIVES AS CXCR3 RECEPTOR MODULATORS | MERCK & CO., INC. (US) | 2007-06-21 | — | — | WO | disclosed |