Biphenyl

Biphenyl

SCHEMBL4872245

C1=CCC([Hf]C2=CC=CC2)=C1.c1ccc(-c2ccccc2)cc1

nearest known ligand 0.39

Full drug profile on Sugi Atlas →

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.39
SLC22A2 O15244 1/20 0.33
SLC22A1 O15245 1/20 0.33
SLC22A3 O75751 1/20 0.33
SLC6A4 P31645 1/20 0.33
CYP1A2 P05177 2/20 0.31
MAPK1 P28482 1/20 0.31
CYP3A4 P08684 1/20 0.31
TAAR1 Q96RJ0 1/20 0.31
HSD17B10 Q99714 1/20 0.31
TDP1 Q9NUW8 1/20 0.31
NOTUM Q6P988 1/20 0.31
MMP3 P08254 1/20 0.31
BCL2L1 Q07817 1/20 0.31
CYP1A1 P04798 1/20 0.30
CYP1B1 Q16678 1/20 0.30
MAPT P10636 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30
HRH3 Q9Y5N1 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL539151 0.83
SCHEMBL27259953 0.83
SCHEMBL7537168 0.82 MAOA (0.38) ALDH1A1TAAR1HSD17B10TDP1SMN1; SMN2
Fluoride SCHEMBL7642269 0.81
Methane SCHEMBL8381074 0.81
Bromide SCHEMBL7888005 0.81
Bromide SCHEMBL8712554 0.81
Iodide SCHEMBL8155731 0.81
Hydrochloric Acid SCHEMBL138985 0.81
SCHEMBL4576530 0.81

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7332551-B2 Partially fluorinated naphthyl-based borates EXXONMOBIL CHEMICAL PATENTS INC. (US) 2008-02-19 US disclosed
US-7077977-B2 Bulky borate activations EXXONMOBIL CHEMICAL PATENTS INC. (US) 2006-07-18 US disclosed
US-6909008-B2 Cocatalyst compositions EXXONMOBIL CHEMICAL PATENTS INC. (US) 2005-06-21 US disclosed
US-20050049436-A1 Partially fluorinated naphthyl-based borates EXXONMOBIL CHEMICAL PATENTS INC. 2005-03-03 US disclosed
US-20040254065-A1 Bulky borate activations EXXONMOBIL CHEMICAL PATENTS INC. 2004-12-16 US disclosed
US-20040199021-A1 DICOPS CONTAINING ACETYLENIC SUBSTITUENTS EXXONMOBIL CHEMICAL PATENTS INC. 2004-10-07 US disclosed
EP-1463738-A1 PARTIALLY FLUORINATED NAPHTHYL-BASED BORATES Exxonmobil Chemical Patents Inc. (US) 2004-10-06 EP disclosed
EP-1461152-A1 BULKY BORATE ACTIVATORS ExxonMobil Chemical Patents Inc. (US) 2004-09-29 EP disclosed
US-20040152591-A1 Polymerized metallocene catalyst composition EXXONMOBIL CHEMICAL PATENTS, INC. 2004-08-05 US disclosed
EP-0927201-B1 CATALYST SYSTEM FOR (CO)POLYMERIZATION OF OLEFINS AND PROCESS FOR THE PREPARATION OF OLEFIN (CO)POLYMERS USING THE CATALYST SYSTEM HYUNDAI PETROCHEMICAL CO LTD (KR) 2004-04-14 EP disclosed
EP-0705848-A2 Compositions useful for olefin polymerization and processes therefor and therewith PHILLIPS PETROLEUM COMPANY (US) 1996-04-10 EP disclosed
EP-0669346-A1 Solid catalyst components for olefin polymerization and use thereof NIPPON OIL CO. LTD. (JP) 1995-08-30 EP disclosed
EP-0434469-B1 Hydrogenation catalyst composition and process for hydrogenating olefinically unsaturated polymer using the same JAPAN SYNTHETIC RUBBER CO LTD (JP) 1995-02-22 EP disclosed
US-5270274-A Catalyst composition for hydrogenating olefinically unsaturated polymers JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1993-12-14 US disclosed
EP-0544304-A1 Catalyst composition for hydrogenating olefinically unsaturated polymers JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1993-06-02 EP disclosed
EP-0303519-B1 POLYMERIZATION OF ETHYLENE MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1993-03-31 EP disclosed
US-5169905-A Using a bis(cyclopentadienyl)transition metal compound and an alkali aluminum organic complex as catalyst JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1992-12-08 US disclosed
EP-0434469-A2 Hydrogenation catalyst composition and process for hydrogenating olefinically unsaturated polymer using the same JAPAN SYNTHETIC RUBBER CO., LTD. (JP) 1991-06-26 EP disclosed
US-4931517-A Polymerization of ethylene MITSUBISHI PETROCHEMICAL COMPANY LIMITED (JP) 1990-06-05 US disclosed
EP-0303519-A1 Polymerization of ethylene MITSUBISHI PETROCHEMICAL CO., LTD. (JP) 1989-02-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040199021-A1 DICOPS CONTAINING ACETYLENIC SUBSTITUENTS AADAC, NAA15, ALG8 ALDH1A1 1329/4885SLC22A2 3775/4885SLC22A1 3827/4885
US-20050049436-A1 Partially fluorinated naphthyl-based borates NBAS, TNK1, POF1B ALDH1A1 4528/4885SLC22A2 2936/4885SLC22A1 2809/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.