Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 12/20 | 0.63 |
| ▸ | MAPK14 | Q16539 | 7/20 | 0.63 |
| ▸ | KDR | P35968 | 2/20 | 0.63 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.63 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.63 |
| ▸ | FLT1 | P17948 | 1/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.51 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CASP1 | P29466 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1648562 | 0.90 | TGFBR1 (0.76) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1646514 | 0.90 | TGFBR1 (0.64) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL7942904 | 0.89 | TGFBR1 (0.66) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4872132 | 0.89 | TGFBR1 (0.61) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1646966 | 0.89 | TGFBR1 (0.62) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1647305 | 0.89 | TGFBR1 (0.62) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4874930 | 0.86 | TGFBR1 (0.84) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1647266 | 0.86 | TGFBR1 (0.59) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4868538 | 0.86 | TGFBR1 (0.83) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4878952 | 0.84 | TGFBR1 (0.58) | TGFBR1MAPK14KDRPRKD1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130245066-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2013-09-19 | — | — | US | claimed |
| US-20080319012-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2008-12-25 | — | — | US | claimed |
| US-20130245066-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2013-09-19 | — | — | US | disclosed |
| US-20130245066-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2013-09-19 | — | — | US | disclosed |
| US-20130245066-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2013-09-19 | — | — | US | disclosed |
| US-20080319012-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2008-12-25 | — | — | US | disclosed |
| US-20080319012-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2008-12-25 | — | — | US | disclosed |
| US-20080319012-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | IN2GEN CO., LTD. (KR) | 2008-12-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130245066-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | ALK, ERBB4, ACVR1 | TGFBR1 93/4885MAPK14 478/4885KDR 9/4885 |
| US-20080319012-A1 | 2-Pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors | ALK, ERBB4, ACVR1 | TGFBR1 93/4885MAPK14 478/4885KDR 9/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.