Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 15/20 | 0.66 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.64 |
| ▸ | KDR | P35968 | 2/20 | 0.64 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.64 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.64 |
| ▸ | FLT1 | P17948 | 1/20 | 0.64 |
| ▸ | FLT4 | P35916 | 1/20 | 0.64 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.51 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.51 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1646514 | 0.91 | TGFBR1 (0.64) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4876173 | 0.91 | TGFBR1 (0.78) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4877766 | 0.90 | TGFBR1 (0.66) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL13988030 | 0.90 | TGFBR1 (0.63) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1647305 | 0.89 | TGFBR1 (0.62) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1646966 | 0.89 | TGFBR1 (0.62) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4872253 | 0.89 | TGFBR1 (0.63) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL1647266 | 0.87 | TGFBR1 (0.59) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4868538 | 0.87 | TGFBR1 (0.83) | TGFBR1MAPK14KDRPRKD1PDGFRA | |
| SCHEMBL4871859 | 0.86 | TGFBR1 (0.58) | TGFBR1MAPK14KDRPRKD1PDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009150547-A2 | 2-PYRIDYL SUBSTITUTED IMIDAZOLES AS ALK4 AND/OR ALK4 INHIBITORS | SK CHEMICALS CO., LTD (KR) | 2009-12-17 | — | — | WO | disclosed |