Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 9/20 | 0.41 |
| ▸ | HTR1D | P28221 | 4/20 | 0.41 |
| ▸ | HTR1B | P28222 | 4/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.41 |
| ▸ | DRD2 | P14416 | 11/20 | 0.41 |
| ▸ | HTR2A | P28223 | 6/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.39 |
| ▸ | HTR2B | P41595 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4877180 | 0.88 | HTR1A (0.38) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4876984 | 0.88 | HTR1A (0.43) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4873454 | 0.86 | DRD2 (0.42) | HTR1ADRD2HTR2AHTR7HTR6 | |
| SCHEMBL4864840 | 0.83 | HTR1A (0.41) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4868514 | 0.82 | HTR1A (0.41) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4873983 | 0.81 | HTR1A (0.43) | HTR1AHTR1DHTR1BSLC6A4KCNH2 | |
| SCHEMBL4876472 | 0.81 | MEN1 (0.42) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4879035 | 0.81 | HTR1A (0.43) | HTR1AHTR1DHTR1BSLC6A4DRD2 | |
| SCHEMBL4867628 | 0.75 | DRD2 (0.35) | HTR1ADRD2HTR2AHTR7ADRA1A | |
| SCHEMBL4874631 | 0.74 | DRD2 (0.42) | HTR1ADRD2HTR2AHTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7393845-B2 | Heteroaryl derivates, their preparation and use | H. LUNDBECK A/S (DK) | 2008-07-01 | — | — | US | claimed |
| US-20080027071-A1 | Novel heteroaryl derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | claimed |
| EP-1399438-B1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2005-12-07 | — | — | EP | claimed |
| US-20040248883-A1 | Novel heteroaryl derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2004-12-09 | — | — | US | claimed |
| EP-1399438-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. Lundbeck A/S (DK) | 2004-03-24 | — | — | EP | claimed |
| WO-2003002556-A1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | H. LUNDBECK A/S (DK) | 2003-01-09 | — | — | WO | claimed |
| US-7393845-B2 | Heteroaryl derivates, their preparation and use | H. LUNDBECK A/S (DK) | 2008-07-01 | — | — | US | disclosed |
| US-20080027071-A1 | Novel heteroaryl derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2008-01-31 | — | — | US | disclosed |
| EP-1399438-B1 | NOVEL HETEROARYL DERIVATIVES, THEIR PREPARATION AND USE | LUNDBECK & CO AS H (DK) | 2005-12-07 | — | — | EP | disclosed |
| US-20040248883-A1 | Novel heteroaryl derivatives, their preparation and use | H. LUNDBECK A/S (DK) | 2004-12-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040248883-A1 | Novel heteroaryl derivatives, their preparation and use | GRIN2C, GRIN2B, HTR1A | HTR1A 3/4885HTR1D 13/4885HTR1B 6/4885 |
| US-20080027071-A1 | Novel heteroaryl derivatives, their preparation and use | GRIN2C, GRIN2B, HTR2C | HTR1A 28/4885HTR1D 56/4885HTR1B 22/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.