Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.46 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.43 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3867553 | 0.85 | MAPT (0.56) | MAPTHPGDL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL30029152 | 0.84 | ALDH1A1 (0.47) | MAPTHPGDL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL364121 | 0.84 | ALDH1A1 (0.47) | MAPTHPGDL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL11651990 | 0.76 | TSHR (0.50) | HPGDALDH1A1CYP4F2CYP4A11CYP3A4 | |
| SCHEMBL5443737 | 0.74 | TAAR1 (0.65) | MAPK1ALDH1A1ALOX12GAACYP3A4 | |
| SCHEMBL128701 | 0.74 | MAPT (0.67) | MAPTHPGDL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL12002 | 0.74 | — | — | |
| SCHEMBL27570328 | 0.72 | TRPA1 (0.56) | MAPTHPGDMEN1ALDH1A1KMT2A | |
| SCHEMBL1548047 | 0.71 | NPC1 (0.53) | MAPTHPGDL3MBTL1CYP2C9CYP2C19 | |
| SCHEMBL6401380 | 0.71 | CYP1A2 (0.62) | MEN1KMT2AALOX12GAACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1937632-A1 | NOVEL COMPOUNDS | Astra Zeneca AB (SE) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007039736-A1 | NOVEL COMPOUNDS | ASTRAZENECA AB (SE) | 2007-04-12 | — | — | WO | disclosed |