Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 9/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | TGFBR2 | P37173 | 2/20 | 0.40 |
| ▸ | MAP3K20 | Q9NYL2 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 2/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.37 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | RAF1 | P04049 | 1/20 | 0.37 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.37 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4862130 | 0.81 | TGFBR1 (0.53) | TGFBR1TGFBR2L3MBTL1THRBADORA2A | |
| SCHEMBL4873701 | 0.80 | AKT1 (0.46) | TGFBR1TGFBR2THRBADORA2AADORA1 | |
| SCHEMBL4872814 | 0.79 | MAPK14 (0.45) | TGFBR1TGFBR2MAP3K20THRBADORA2A | |
| SCHEMBL4868119 | 0.78 | MAPK14 (0.60) | TGFBR1TGFBR2THRBADORA2AADORA1 | |
| SCHEMBL4872159 | 0.78 | TGFBR1 (0.55) | TGFBR1TGFBR2THRBADORA2AADORA1 | |
| SCHEMBL4865628 | 0.78 | MAPK14 (0.44) | TGFBR1TGFBR2NPC1THRBADORA2A | |
| SCHEMBL412069 | 0.78 | TGFBR1 (0.42) | TGFBR1TGFBR2MAP3K20CYP2D6THRB | |
| SCHEMBL4869284 | 0.78 | MAPT (0.43) | TGFBR1NPC1L3MBTL1THRBMAPK14 | |
| SCHEMBL4867464 | 0.78 | MAPK14 (0.46) | TGFBR1TGFBR2THRBADORA2AADORA1 | |
| SCHEMBL4865571 | 0.77 | BAZ2B (0.44) | TGFBR1TGFBR2MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7365066-B2 | Pyrazolopyridine derivatives as pharmaceutical agents | ELI LILLY AND COMPANY (US) | 2008-04-29 | — | — | US | claimed |
| EP-1543001-B1 | PYRAZOLOPYRIDINE DERIVATIVES AS TGF BETA SIGNAL TRANSDUCTION INHIBITORS FOR THE TREATMENT OF CANCER | LILLY CO ELI (US) | 2007-08-15 | — | — | EP | disclosed |