Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APAF1 | O14727 | 11/20 | 0.97 |
| ▸ | NPC1 | O15118 | 6/20 | 0.97 |
| ▸ | RAB9A | P51151 | 5/20 | 0.97 |
| ▸ | MAPT | P10636 | 13/20 | 0.78 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.78 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.78 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.78 |
| ▸ | POLB | P06746 | 5/20 | 0.78 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.78 |
| ▸ | HPGD | P15428 | 2/20 | 0.78 |
| ▸ | HTT | P42858 | 6/20 | 0.76 |
| ▸ | LMNA | P02545 | 4/20 | 0.76 |
| ▸ | MITF | O75030 | 4/20 | 0.76 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.76 |
| ▸ | CDC25A | P30304 | 2/20 | 0.67 |
| ▸ | CDC25B | P30305 | 2/20 | 0.67 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.61 |
| ▸ | GAA | P10253 | 4/20 | 0.61 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5807881 | 0.99 | APAF1 (1.00) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7247303 | 0.88 | MAPT (0.97) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL16297187 | 0.87 | APAF1 (1.00) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7246128 | 0.86 | MAPT (0.76) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL4872810 | 0.86 | MAPT (0.76) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL16297041 | 0.86 | MAPT (0.76) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7247910 | 0.86 | APAF1 (0.76) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL24355094 | 0.85 | MITF (0.73) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL2464285 | 0.85 | APAF1 (0.72) | APAF1NPC1RAB9AMAPTALDH1A1 | |
| SCHEMBL7243360 | 0.85 | APAF1 (0.72) | APAF1NPC1RAB9AMAPTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8513437-B2 | Pyrrolidino-1,4-naphthoquinone deriviatives and their use for treating malignancies and cardiovascular diseases | BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IS) | 2013-08-20 | — | — | US | disclosed |
| US-20080300274-A1 | Novel Pyrrolidino-1,4-Naphthoquinone Deriviatives and their Use for Treating Malignancies and Cardiovascular Diseases | BEN GURION UNIVERSITY OF THE NEGEV RESEARCH AND DEVELOPMENT AUTHORITY (IL) | 2008-12-04 | — | — | US | disclosed |
| WO-2006011136-A9 | NOVEL NAPHTHOQUINONE DERIVATIVES AND USES THEREOF | VELOPMENT AUTHORITY BEN GURION (IL) | 2006-04-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080300274-A1 | Novel Pyrrolidino-1,4-Naphthoquinone Deriviatives and their Use for Treating Malignancies and Cardiovascular Diseases | MAPK1, MAP3K1, MAP3K20 | APAF1 1872/4885NPC1 1969/4885RAB9A 1585/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.