Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIP4K2A | P48426 | 4/20 | 0.39 |
| ▸ | PIP4K2B | P78356 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NAMPT | P43490 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL48673 | 0.81 | BACE1 (0.39) | ALDH1A1LMNARECQLTDP1 | |
| SCHEMBL2343374 | 0.74 | CA2 (0.36) | ALDH1A1HTT | |
| SCHEMBL10868056 | 0.70 | HPGD (0.67) | PIP4K2APIP4K2BHPGDSMN1; SMN2MAPK1 | |
| SCHEMBL26728374 | 0.65 | PTK2 (0.54) | PIP4K2APIP4K2BHPGDSMN1; SMN2NAMPT | |
| SCHEMBL5673110 | 0.63 | CYP26A1 (0.59) | HPGDSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL12054668 | 0.62 | KEAP1 (0.75) | HPGDSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL27758157 | 0.62 | CA12 (0.46) | HPGDSMN1; SMN2KDM4EALDH1A1LMNA | |
| SCHEMBL2746245 | 0.61 | CA12 (0.50) | PIP4K2APIP4K2BHPGDSMN1; SMN2KDM4E | |
| SCHEMBL5674433 | 0.61 | CA12 (0.45) | HPGDSMN1; SMN2MAPK1KDM4EALDH1A1 | |
| SCHEMBL15456908 | 0.61 | HPGD (0.50) | PIP4K2APIP4K2BHPGDSMN1; SMN2KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129541-B2 | 5-phenylthiazole derivatives and use as PI3 kinase inhibitors | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100093690-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | BRUCE IAN | 2010-04-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100093690-A1 | 5-PHENYLTHIAZOLE DERIVATIVES AND USE AS PI3 KINASE INHIBITORS | PIK3CA, PIK3R5, PIP5K1B | PIP4K2A 15/4885PIP4K2B 13/4885HPGD 3220/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.