Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.42 |
| ▸ | TRIM24 | O15164 | 4/20 | 0.41 |
| ▸ | HTR6 | P50406 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4866321 | 0.90 | ALDH1A1 (0.57) | ALDH1A1KMT2AMAPTMEN1ALOX12 | |
| SCHEMBL4876385 | 0.89 | HTR6 (0.49) | ALDH1A1KMT2AMAPTMEN1ALOX12 | |
| SCHEMBL4876689 | 0.89 | CES1 (0.54) | ALDH1A1KMT2AMAPTHTR6DRD2 | |
| SCHEMBL4873695 | 0.89 | ALDH1A1 (0.58) | ALDH1A1KMT2AMAPTMEN1MAPK1 | |
| SCHEMBL4874044 | 0.87 | ALDH1A1 (0.62) | ALDH1A1KMT2AMAPTMEN1HTR6 | |
| SCHEMBL4876786 | 0.87 | ALDH1A1 (0.56) | ALDH1A1KMT2AMAPTMEN1ALOX12 | |
| SCHEMBL6617076 | 0.87 | ALDH1A1 (0.60) | ALDH1A1KMT2AMAPTMEN1MAPK1 | |
| SCHEMBL4876622 | 0.86 | ALDH1A1 (0.60) | ALDH1A1KMT2AMEN1MAPK1CYP3A4 | |
| SCHEMBL4868720 | 0.83 | MAPT (0.49) | ALDH1A1KMT2AMAPTMEN1HTR6 | |
| SCHEMBL4869725 | 0.83 | HTR2A (0.51) | ALDH1A1MAPTMAPK1ATMHTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7408067-B2 | Aza-cyclic compounds as modulators of acetylcholine receptors | MERCK + CO., INC. (US) | 2008-08-05 | — | — | US | disclosed |
| US-20050070520-A1 | Aza-cyclic compounds as modulators of acetylcholine receptors | MERCK SHARP & DOHME CORP. | 2005-03-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070520-A1 | Aza-cyclic compounds as modulators of acetylcholine receptors | CHRNG, CHRNA4, CHRNB4 | ALDH1A1 1088/4885KMT2A 2028/4885MAPT 3850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.