SCHEMBL4875214

SCHEMBL4875214

O=C(O)c1cc2c(s1)c(C1CCCCC1)c(-c1ccc3nc(-c4ccccc4F)ccc3c1)n2CC(=O)N1CCS(=O)(=O)CC1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 2/20 0.33
ALDH1A1 P00352 1/20 0.33
GAA P10253 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
GRIN2B Q13224 4/20 0.32
SMO Q99835 1/20 0.32
NPC1 O15118 2/20 0.32
RAB9A P51151 2/20 0.32
CYP2D6 P10635 1/20 0.31
HRH1 P35367 1/20 0.31
GRM5 P41594 1/20 0.31
TNKS O95271 1/20 0.31
PARP1 P09874 1/20 0.31
PARP2 Q9UGN5 1/20 0.31
ALOX5AP P20292 1/20 0.31
FEN1 P39748 1/20 0.31
MAPT P10636 1/20 0.30
JAK1 P23458 1/20 0.30
DHODH Q02127 1/20 0.30
MEN1 O00255 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4877145 0.94 GRIN2B (0.37) KMT2AALDH1A1GAASMN1; SMN2GRIN2B
SCHEMBL3931763 0.91 GRIN2B (0.39) KMT2AALDH1A1GAASMN1; SMN2GRIN2B
SCHEMBL4876035 0.91 GRIN2B (0.39) GRIN2BSMOHRH1ALOX5APFEN1
SCHEMBL4875207 0.88 GRIN2B (0.33) GRIN2BNPC1RAB9AGRM5ALOX5AP
SCHEMBL4877368 0.88 SMN1; SMN2 (0.31) KMT2AALDH1A1GAASMN1; SMN2
SCHEMBL4870793 0.88 CBX7 (0.37) KMT2AALDH1A1GAASMN1; SMN2GRIN2B
SCHEMBL4877238 0.87 ALDH1A1 (0.33) KMT2AALDH1A1GAASMN1; SMN2SMO
SCHEMBL4868332 0.86 ALDH1A1 (0.37) KMT2AALDH1A1GAASMN1; SMN2GRIN2B
SCHEMBL4876718 0.86 ALDH1A1 (0.39) KMT2AALDH1A1GAASMN1; SMN2GRIN2B
SCHEMBL4875238 0.86 ALDH1A1 (0.39) KMT2AALDH1A1GAASMN1; SMN2GRIN2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed
US-20080051384-A1 ANTIVIRAL AGENTS GENELABS TECHNOLOGIES, INC. 2008-02-28 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20080051384-A1 ANTIVIRAL AGENTS EIF2AK2, MAVS, ZC3HAV1 KMT2A 4254/4885ALDH1A1 1357/4885GAA 66/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.