Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 1/20 | 0.70 |
| ▸ | HTR2A | P28223 | 6/20 | 0.64 |
| ▸ | HTR2C | P28335 | 5/20 | 0.64 |
| ▸ | CNR1 | P21554 | 1/20 | 0.60 |
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | ESR1 | P03372 | 1/20 | 0.52 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL5130227 | 0.98 | HTR6 (0.68) | HTR6HTR2AHTR2CCNR1DRD2 | |
| Cyanide SCHEMBL28580911 | 0.95 | HTR6 (0.65) | HTR6HTR2AHTR2CCNR1DRD2 | |
| SCHEMBL22221978 | 0.93 | HTR6 (0.61) | HTR6HTR2AHTR2CCNR1DRD2 | |
| SCHEMBL14074161 | 0.87 | HTR2A (0.63) | HTR6HTR2AHTR2CCNR1DRD2 | |
| SCHEMBL6476562 | 0.85 | HTR6 (0.55) | HTR6HTR2AHTR2CCNR1DRD2 | |
| SCHEMBL22221974 | 0.85 | HTR6 (0.55) | HTR6HTR2AHTR2CCNR1DRD2 | |
| SCHEMBL7613059 | 0.83 | KDM4E (0.64) | HTR6HTR2AHTR2CKDM4EALDH1A1 | |
| SCHEMBL2789743 | 0.83 | HTR6 (0.71) | HTR6HTR2AHTR2CCNR1DRD2 | |
| SCHEMBL7995810 | 0.82 | GNRHR (0.54) | — | |
| SCHEMBL10933049 | 0.82 | HTR2A (0.69) | HTR2AHTR2CCNR1DRD2ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7625919-B2 | 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-7625919-B2 | 4-azasteroid derivatives as androgen receptor modulators | MERCK & CO., INC. (US) | 2009-12-01 | — | — | US | disclosed |
| US-20080262035-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | MERCK & CO., INC. | 2008-10-23 | — | — | US | disclosed |
| US-20080221157-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGE (IT) | 2008-09-11 | — | — | US | disclosed |
| CN-101107220-A | Amide derivatives as inhibitors of histone deacetylase | ANGELETTI P INST RICHERCHE BIO (IT) | 2008-01-16 | — | — | CN | disclosed |
| EP-1768955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI S.P.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| EP-1768956-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | Istituto di Richerche di Biologia Molecolare P. Angeletti S.p.A. (IT) | 2007-04-04 | — | — | EP | disclosed |
| WO-2006005941-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI S.P.A. (IT) | 2006-01-19 | — | — | WO | disclosed |
| WO-2006005955-A1 | AMIDE DERIVATIVES AS INHIBITORS OF HISTONE DEACETYLASE | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P ANGELETTI SPA (IT) | 2006-01-19 | — | — | WO | disclosed |
| US-6486153-B1 | Phenylindole derivatives as 5-HT2A receptor ligands | MERCK SHARP & DOHME LTD. | 2002-11-26 | — | — | US | disclosed |
| WO-1999011619-A1 | PHENYLINDOLE DERIVATIVES AS 5-HT2A RECEPTOR LIGANDS | MERCK SHARP & DOHME LIMITED (GB) | 1999-03-11 | — | — | WO | disclosed |
| EP-0892963-A1 | METHOD OF CREATING AND SEARCHING A MOLECULAR VIRTUAL LIBRARY USING VALIDATED MOLECULAR STRUCTURE DESCRIPTORS | Patterson, David E. (US) | 1999-01-27 | — | — | EP | disclosed |
| WO-1997027559-A1 | METHOD OF CREATING AND SEARCHING A MOLECULAR VIRTUAL LIBRARY USING VALIDATED MOLECULAR STRUCTURE DESCRIPTORS | PATTERSON DAVID E (US) | 1997-07-31 | — | — | WO | disclosed |
| EP-0623138-B1 | NEW ADENOSINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | UNION PHARMA SCIENT APPL (FR) | 1997-05-21 | — | — | EP | disclosed |
| US-5480983-A | ANALGESICS, HYPOTENSIVE AGENTS | LABORATOIRES UPSA (FR) | 1996-01-02 | — | — | US | disclosed |
| EP-0623138-A1 | NEW ADENOSINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | UNION PHARMA SCIENT APPL (FR) | 1994-11-09 | — | — | EP | disclosed |
| WO-1993014102-A1 | NEW ADENOSINE DERIVATIVES, PREPARATION METHODS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | LABORATOIRES UPSA (FR) | 1993-07-22 | — | — | WO | disclosed |
| US-3956267-A | Indole-containing disazo dyestuffs having a sulfatoalkyleneoxy-substituent | BAYER AKTIENGESELLSCHAFT (DT) | 1976-05-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080262035-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC11 | HTR6 1039/4885HTR2A 1259/4885HTR2C 1994/4885 |
| US-20080221157-A1 | Amide Derivatives as Inhibitors of Histone Deacetylase | HDAC1, HDAC5, HDAC4 | HTR6 1664/4885HTR2A 2204/4885HTR2C 2870/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.