Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.39 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 6/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4875319 | 0.85 | MAPT (0.38) | PTGS2MAPTGRM5CYP19A1TGFBR1 | |
| SCHEMBL4875437 | 0.83 | MAPT (0.47) | PTGS2MAPTGRM5CYP19A1TGFBR1 | |
| SCHEMBL4877197 | 0.78 | MAPT (0.45) | PTGS2MAPTGRM5HTT | |
| SCHEMBL4859211 | 0.77 | MAPT (0.42) | PTGS2MAPTGRM5 | |
| SCHEMBL4869156 | 0.77 | MAPT (0.36) | PTGS2MAPTGRM5 | |
| SCHEMBL4812854 | 0.76 | MAPT (0.58) | MAPTHTT | |
| SCHEMBL4808663 | 0.75 | CYP2A6 (0.54) | PTGS2MAPTGRM5CYP19A1HTT | |
| SCHEMBL4878767 | 0.75 | MAPT (0.54) | PTGS2MAPTGRM5CYP19A1TGFBR1 | |
| SCHEMBL4810083 | 0.75 | MAPT (0.39) | PTGS2MAPTGRM5 | |
| SCHEMBL4806012 | 0.75 | TGFBR1 (0.44) | PTGS2MAPTGRM5CYP19A1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | claimed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PDE5A, PDE3B, PDE12 | GRIA1 1448/4885GRIA3 1052/4885PDE4D 23/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.