Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 3/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | PPP1CA | P62136 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.38 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.37 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4859211 | 0.89 | MAPT (0.42) | MAPTCYP2A6PTGS1GRM5CYP2E1 | |
| SCHEMBL4806012 | 0.86 | TGFBR1 (0.44) | MAPTTGFBR1CYP2A6PTGS1GRM5 | |
| SCHEMBL4878767 | 0.86 | MAPT (0.54) | MAPTTGFBR1GRM5CYP19A1PTGS2 | |
| SCHEMBL4878282 | 0.86 | MAPT (0.46) | MAPTBIRC5TGFBR1PTGS1CYP1A2 | |
| SCHEMBL4875319 | 0.85 | MAPT (0.38) | MAPTTGFBR1CYP2A6PTGS1CYP1A2 | |
| SCHEMBL4810083 | 0.84 | MAPT (0.39) | MAPTCYP2A6PTGS1GRM5CYP2E1 | |
| SCHEMBL4812854 | 0.83 | MAPT (0.58) | MAPTCYP1A2CYP2C9CYP2C19PPP1CA | |
| SCHEMBL4877197 | 0.83 | MAPT (0.45) | MAPTCYP2A6PTGS1CYP1A2CYP2C9 | |
| SCHEMBL4875800 | 0.83 | IRAK4 (0.43) | MAPTCYP2A6PTGS1CYP1A2CYP2C9 | |
| SCHEMBL4875388 | 0.83 | GRIA1 (0.39) | MAPTTGFBR1GRM5CYP19A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | claimed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PFIZER INC | 2008-04-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080090834-A1 | SELECTIVE AZOLE PDE10A INHIBITOR COMPOUNDS | PDE5A, PDE3B, PDE12 | MAPT 964/4885BIRC5 931/4885TGFBR1 1344/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.