Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 1/20 | 0.53 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.53 |
| ▸ | HRH1 | P35367 | 1/20 | 0.52 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.43 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | PIM1 | P11309 | 1/20 | 0.43 |
| ▸ | PRKACA | P17612 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | CLK2 | P49760 | 1/20 | 0.43 |
| ▸ | PRKX | P51817 | 1/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.43 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1895833 | 0.89 | HRH1 (0.66) | CHRNB2CHRNA4HRH1ROCK1CHUK | |
| SCHEMBL1813676 | 0.84 | SLC6A2 (0.48) | HRH1HTR1ASLC6A2 | |
| SCHEMBL226349 | 0.81 | HRH1 (0.78) | CHRNB2CHRNA4HRH1PRKCZHTR2C | |
| SCHEMBL14828522 | 0.81 | HRH1 (0.78) | CHRNB2CHRNA4HRH1PRKCZHTR2C | |
| SCHEMBL2523551 | 0.81 | HRH1 (0.78) | CHRNB2CHRNA4HRH1PRKCZHTR2C | |
| SCHEMBL14775243 | 0.81 | HRH1 (0.56) | CHRNB2CHRNA4HRH1ROCK1ROCK2 | |
| Hydrochloric Acid SCHEMBL796443 | 0.79 | HRH1 (0.75) | CHRNB2CHRNA4HRH1PRKCZHTR2C | |
| SCHEMBL4067092 | 0.79 | PRKCZ (0.56) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL3133920 | 0.79 | PRKCZ (0.56) | CHRNB2CHRNA4HRH1PRKCZROCK1 | |
| SCHEMBL7000861 | 0.79 | PRKCZ (0.56) | CHRNB2CHRNA4HRH1PRKCZROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019238067-A1 | PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF | BEIGENE, LTD. (KY) | 2019-12-19 | — | — | WO | disclosed |
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | MERCK PATENT GMBH (DE) | 2008-09-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080214582-A1 | Purine Derivatives as Inhibitors of Receptor Tyrosine Kinase Activity | TIE1, FLT1, RET | CHRNB2 2879/4885CHRNA4 3592/4885HRH1 521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.