Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 18/20 | 0.43 |
| ▸ | BACE2 | Q9Y5Z0 | 8/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.35 |
| ▸ | CTSD | P07339 | 6/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4737191 | 0.89 | BACE1 (0.44) | BACE1BACE2CTSDCYP11B1CYP11B2 | |
| SCHEMBL4736296 | 0.89 | BACE1 (0.42) | BACE1BACE2CTSD | |
| SCHEMBL4737450 | 0.87 | CTSD (0.38) | BACE1BACE2CTSD | |
| SCHEMBL4738814 | 0.85 | BACE1 (0.32) | BACE1BACE2CTSD | |
| SCHEMBL4227283 | 0.75 | BACE1 (0.39) | BACE1BACE2CTSD | |
| SCHEMBL4240278 | 0.74 | BACE1 (0.46) | BACE1BACE2CTSD | |
| SCHEMBL4232217 | 0.73 | HSD11B1 (0.36) | BACE1BACE2CTSD | |
| SCHEMBL4232737 | 0.73 | BACE1 (0.38) | BACE1BACE2CTSD | |
| Acetic Acid SCHEMBL4798172 | 0.72 | BACE1 (0.79) | BACE1BACE2CTSD | |
| SCHEMBL4237703 | 0.72 | BACE1 (0.44) | BACE1BACE2CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080161269-A1 | Compounds 620 | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | US | claimed |
| US-20080161269-A1 | Compounds 620 | ASTRAZENECA AB (SE) | 2008-07-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080161269-A1 | Compounds 620 | MAPT, PSEN1, PSEN2 | BACE1 4/4885BACE2 29/4885KCNH2 3587/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.